Protein Chromatography: Process Development and Scale-Up by Giorgio Carta, Alois Jungbauer

Protein Chromatography: Process Development and Scale-Up



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Protein Chromatography: Process Development and Scale-Up Giorgio Carta, Alois Jungbauer ebook
Format: pdf
ISBN: 3527318194, 9783527318193
Publisher: Wiley, John & Sons, Incorporated
Page: 364


Rapid technology transfer and scale-up to cGMP manufacturing scale. With the responsibility of scaling-up an in-vitro translation process for scFv- fragments. Process Scale-up of Protein and. See also our laboratory of downstream process development. Polypeptide In process chromatography, however, the . Each unit contains 16 layers of Mustang membrane, exactly the same as the larger Mustang units, allowing accurate scale-up from process development to pilot and process scale, especially with regards to flow/differential pressure and dynamic binding capacity. More process includes protein purification in different scale using various chromatography techniques. Scientist-Early Purification Process Development (325717) - The ion exchange chromatography using AKTA FPLC systems (Unicorn software) as using standard methods to purify proteins from the mg to gram scale. Experience with scale-up and GMP manufacturing is desirable but not necessary. Development of gel media and columns for protein chromatography . Our Process Development platform has substantial experience in the optimization and scale up of production schemes in compliance with GMP guidelines. In addition, the large pores eliminate the size exclusion effect allowing full access to the binding chemistry for very large proteins, plasmids and viruses. Analysis and quantitation of fractions during process development.